THE OPTICAL CHEMISTRY AND SIGNAL TRANSDUCTION GROUP

  • HeLa cells expressing GFP-CXCR4(green) receptor and βγ9-mCherry (Red)

  • Activation of CXCR4 induces translocation of bg into internal membranes

Ability to control cell signaling is a crucial aspect of pharmacology and disease management. Lack of approaches to do so precisely in space and time in single cells has been an impediment to exert control over cell behavior both experimentally and therapeutically. Interfacing research strategies in chemistry, biology, and biophysics, we develop and employ subcellular optogenetic approaches to control, visualize and dissect signal transduction pathways pertaining to pathologically important cell behaviors such as cancer cell migration and neuronal damage repair

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RESEARCH HIGHLIGHTS